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Istradefylline 40 mg/day increased peak ranges and AUC of CYP3A4 substrates in clinical trials. This outcome wasn't observed with istradefylline 20 mg/working day. Consider dose reduction of delicate CYP3A4 substrates.Headache, intermittent claudication, muscle pains, numbness, or coldness and pallor of your digits could occur with chronic intoxica